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Abstract #0436

Region-of-interest size of hepatic 2D MR elastography decreases with increasing R2* for gradient-echo but not spin-echo techniques

Cheng William Hong1, Adrija Mamidipalli1, Ethan Z Sy1, Jonathan C Hooker1, Calvin Andrew Tran1, Tanya Wolfson2, Soudabeh Fazeli Dehkordy1, Scott B Reeder3, Rohit Loomba4, and Claude B Sirlin1

1Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Computational and Applied Statistics Laboratory, University of California, San Diego, San Diego, CA, United States, 3Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin, Madison, Madison, WI, United States, 4NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, CA, United States

MR elastography (MRE) is an emerging technique for the non-invasive assessment of hepatic stiffness and fibrosis, and can be based on gradient-echo (GRE) or spin-echo (SE) acquisition. This study demonstrates that 2D-SE provides significantly larger reliable-wave-quality regions-of-interest (ROIs) than 2D-GRE at 3T. Additionally, 2D-GRE ROI sizes are negatively correlated with hepatic R2*, while 2D-SE ROI sizes are not associated with R2*. This suggests that 2D-SE may be the preferred MRE sequence at 3T and in patients with known iron overload.

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