Inhomogeneous magnetization transfer (ihMT) is a new endogenous contrast mechanism that has been proposed for imaging myelinated tissues. The dipolar interaction underlying the ihMT effect is intrinsically anisotropic, exhibiting the well-known (3cos²θ -1) angle dependency. Here we report experimental evidence of the anisotropy of ihMT in white matter and we derive a realistic theoretical model combining the angular dependency of the myelin lineshape and dipolar-order RF saturation theory.
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