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Abstract #0486

Self-gated 23Na-MRI of human lung with separate reconstruction of two respiratory states at 7T

Tanja Platt1, Reiner Umathum1, Armin M. Nagel1,2, Peter Bachert1, Mark E. Ladd1, Mark O. Wielp├╝tz3, Hans-Ulrich Kauczor3, and Nicolas G. R. Behl1

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 3Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany

23Na-MRI at 7T can give valuable insights into lung physiology because 23Na signals are linked to sodium-potassium-ATPase and to fluid balance. However, low NMR sensitivity and low in-vivo concentrations of Na+ ions in-vivo limit the achievable spatial resolution and prolong acquisition times. In this study a retrospective self-gated reconstruction was used to reduce motion artifacts in free-breathing 23Na-MRI of human lung. The presented method allows for the reconstruction of 23Na images which correspond to two respiratory motion states for free-breathing volunteers and patients. 3D Dictionary-Learning Compressed-Sensing reconstruction was shown to markedly reduce image noise.

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