With rising incidents of fatty liver disease and metabolic disorder there is a need for biomarkers that can assess progression to steatohepatitis and other forms of liver damage. Oxidative stress in the mitochondria may play a central role in disease progression, with glutathione acting as the main antioxidant. In this study we developed a method previously suggested to monitor hepatic glutathione production in vivo by administering oral [2-13C] labelled glycine and using 13C MRS to measure conversion to glutathione. Following optimization, we tested variability in 8 healthy volunteers over two visits.
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