A new method is presented for acquiring multiple image contrasts simultaneously. The technique reduces patient examination times and facilitates accurate image registration between contrasts. This work focuses on a variant of the method, in which readout-segmented EPI (rs-EPI) is used to perform high-quality, navigator-corrected, diffusion-weighted imaging simultaneously with a T2*-weighted acquisition. This combination of contrasts has clinical significance in acute stroke, providing a registered data set for assessing the infarct and possibility of associated hemorrhage. The proposed method modifies the contrast as a function of slice position and uses blipped CAIPIRINHA and slice-GRAPPA to separate the contrasts into individual images.