Peri-infarct region (PIR), containing the viable but injured myocardium, has been related to the occurrence of ventricular arrhythmia. Reliable in vivo detection of arrhythmogenic region presents significant challenge. While delayed enhanced MRI (DEMRI) with gadolinium (Gd) detects the myocardial infarction, the non-specific property does not detect the viable but injured cardiomyocytes in the PIR. Manganese (Mn) enters the live cells via L-type calcium channel, and enables dual enhancement technique to identify the overlapping viable region in PIR. We measured the correlation between the volume of the PIR and inducibility of ventricular arrhythmia using porcine ischemia reperfusion model.
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