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Abstract #0575

Geometric Distortion Correction of Diffusion-Weighted MRI and its Effect on quantitative ADC analysis

Gabriel Nketiah1, Kirsten M. Seln├Žs1,2, Elise Sandsmark1, Jose R. Teruel3, Tone F. Bathen1,2, and Mattijs Elschot1

1Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, 2St. Olavs Hospital,Trondheim University Hospital, Trondheim, Norway, 3Department of Radiology, University of California San Diego, CA, United States

Tissue water diffusion (ADC) quantification through diffusion-weighted imaging (DWI) currently plays an integral clinical role in prostate cancer. The echo-planar imaging technique employed in DWI is however prone to geometric distortion due to static magnetic field (B0) inhomogeneity. We investigated the effect of the correction of this distortion on the quantification of ADC values in the prostate. Our study showed that there is a significant association between the amount of distortion (mm) and the difference between ADC values before and after correction, which implies that correction for this could be necessary, especially for voxel-based quantitative analysis.

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