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Abstract #0596

MRI visualization of brain-like tissue formation following implantation of neural precursors into in cerebrospinal fluid

Nikorn Pothayee1, Dragan Maric2, Kathryn Sharer1, Jung-Hwa Tao-Cheng 3, Stephen Dodd1, Alec Calac1, James Pickel4, and Alan Koretsky1

1Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, 2Flow Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, 3Electron Microscopy Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, 4Transgenic Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

Neural stem cell transplantation has been hailed as a promising approach for treatment of neurological diseases. While most in vivo studies have implanted cells into specific sites in brain tissue, little is known whether the cerebrospinal fluid (CSF) provides a permissive environment in cultivating tissue growth. Here, using MRI, we investigate whether early neural precursor cells could initiate a large-scale formation of new brain tissue in the CSF of adult rat.

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