Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease characterized by motor neuron loss and eventual paralysis and respiratory failure. The SOD1 transgenic mouse model exhibits many aspects of human ALS and is useful for evaluating treatment strategies. MRI of the nervous system can provide the critical insights to motor neuron and upper body functional deterioration in ALS. In this study, we applied T2 and DTI to assess gray and white matter degeneration in the brain and cervical spine in a SOD1 mouse model.
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