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Abstract #0630

Hyperpolarized [1,4-13C2]Fumarate is a probe of necrosis in myocardial infarction

Jack Julian James Jenkins Miller1,2,3, Angus Zoen Lau1,4, Giles McMullen-Klein1, Andrew Lewis1, Vicky Ball1, Carolyn Carr1, Ferdia Gallagher5, Damian John Tyler1,2, and Marie Schroder6

1Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, 2Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 3Department of Physics, University of Oxford, Oxford, United Kingdom, 4Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 5Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 6MR Centret, Ã…rhus University Hospital, Skejby, Denmark

Previous work has shown that hyperpolarized [1,4-13C2]fumarate is a probe of cellular necrosis. We demonstrate here that the ratio of cardiac hyperpolarized malate to fumarate is increased by a factor of $$$\sim$$$82 one day after cryoinduced myocardial infarction in rats, decreasing to an $$$\sim$$$30-fold increase one week after injury. We additionally image this injury with a novel spiral multiband pulse sequence. Hyperpolarized fumarate therefore forms a sensitive probe of myocardial injury in vivo, and could form a clinical monitor of cellular damage and necrosis after infarction.

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