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Abstract #0636

Using transient intrinsic torsional shear wave propagation to measure Left Ventricular Myocardial stiffness with a 2D pencil beam navigator at 0.5ms temporal resolution: Initial results from phantom studies and volunteers

Jessica Webb1,2, Jurgen Runge1,3, Jordi Martorell4, Gerald Carr-White1,2, Reza Razavi1,2, David Nordsletten1, and Ralph Sinkus1

1Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, 2Department of Cardiology, Guys and St Thomas' NHS Trust, London, United Kingdom, 3Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 4Department of Chemical Engineering, Universitat Ramon Llull, Barcelona, Spain

Heart Failure with preserved Ejection Fraction is common, associated with high morbidity and mortality, and is challenging to diagnose. We have developed a novel patient friendly non-invasive technique to quantify myocardial stiffness using transient MR Elastography. Aortic valve closure results in a shear wave propagating through the myocardium. The torsional wave propagation can be visualised using a 2D pencil beam navigator positioned along the myocardium, using four breath holds each 15 seconds. With a temporal resolution of 0.5ms this technique can be used in all patients in sinus rhythm. Increased myocardial stiffness results in increased speed of shear wave propagation.

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