Meeting Banner
Abstract #0647

Longitudinal characterization of deformation-induced skeletal muscle damage by T2-mapping, DWI and MRE

Jules L. Nelissen1,2, Willeke A. Traa3, Larry de Graaf1, Cees W. J. Oomens3, Jurgen H. Runge4,5, Ralph Sinkus4, Klaas Nicolay1, Aart J. Nederveen5, Martijn Froeling6, and Gustav J. Strijkers2

1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, 2Preclinical and Translational MRI, Academic Medical Center, Amsterdam, Netherlands, 3Biomechanics of Soft Tissues, Eindhoven University of Technology, Eindhoven, Netherlands, 4Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, 5Radiology, Academic Medical Center, Amsterdam, Netherlands, 6Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Skeletal muscle injury is often accompanied by fibrosis, fatty infiltration, and edema. There is great need for imaging readouts to detect and quantify such compositional changes, which would aid understanding and greatly assist in the development of emerging therapies. The goal of this work was to use a multi-modality approach, combining magnetic resonance elastography (MRE; muscle stiffness, fibrosis) with diffusion-weighted imaging (DWI; myocyte integrity) and T2-mapping (edema, inflammation) to provide a comprehensive assessment of muscle injury development and regeneration. The multi-modality assessment provided differential readouts of the deformation-induced muscle injury development and regeneration process.

This abstract and the presentation materials are available to members only; a login is required.

Join Here