To introduce simultaneous multiple slices (SMS) turbo spin echo (TSE) and to evaluate its image quality and diagnostic accuracy for lesions in the knee. Participants were examined by SMS and routine TSE sequences. Both sequences were evaluated by three radiologists with subjective and objective scores in T1- and PD-weighted images. The diagnostic value in lesions was evaluated. SMS requires less scan time and offers similar imaging quality and diagnostic rate compared to routine TSE sequence. SMS is a valuable technique for MR examination of the knee.