Abstract #0674

Discrimination of Malignant versus Benign Mediastinal Lymph Nodes Using Diffusion MRI with An IVIM Analysis

Li-Ping Qi^1,2, Wan-Pu Yan³, Ke-Neng Chen³, Zheng Zhong^2,4, Kejia Cai^2,5, Xiao-Ting Li¹, Ying-Shi Sun¹, and Xiaohong Joe Zhou^2,6

¹Radiology, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China, ²Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, ³Thoracic Surgery, Peking University Cancer Hospital and Institute, Beijing, People's Republic of China, ⁴Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ⁵Radiology and Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ⁶Radiology, Neurosurgery, and Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

Noninvasive discrimination of mediastinal lymph nodes (MLN) is crucial for management of cancer patients such as those with non-small cell lung carcinoma. This study aims at investigating the value of IVIM diffusion parameters (D, D*, and f) as well as ADC for discrimination of malignant and benign MLN. A total of 91 MLN from 35 patients with histopathologic proven lesions were studied. D and f of malignant mediastinal lymph nodes were significantly different from those in the benign ones. The combination of f and D produced the highest diagnostic performance as evaluated by a receiver operating characteristic (ROC) analysis.

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