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Abstract #0683

Extreme ASL:  Challenges and Solutions to Improve Perfusion Imaging in Patients with Markedly Prolonged Arterial Transit Delays

Jia Guo1, Audrey Fan1, Marc R. Lebel2, Samantha Holdsworth1, Ajit shankaranarayanan3, and Greg Zaharchuk1

1Radiology, Stanford University, Stanford, CA, United States, 2GE Healthcare, Calgary, Canada, 3GE Healthcare, Menlo Park, CA, United States

It is known that if labeling parameters are not properly adjusted in the presence of prolonged arterial transit delays (ATDs), perfusion may be underestimated using arterial spin labeling (ASL), yielding false negatives and possibly unnecessary interventions. In this study we evaluate the cases where the prolonged ATDs due to cerebrovascular disease posed challenges to perfusion quantification using ASL. Some possible solutions, which we term ‘extreme ASL’, were explored and discussed.

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