Cerebrum microstructure has been extensively investigated with diffusion-weighted MRI, but little attention has been dedicated to the microstructural characterisation of the cerebellum.
We considered an anatomical parcellation of the cerebellum and fitted a multi-compartment model to diffusion data exploiting the spherical mean technique, which provides parametric maps unconfounded by the underlying fibre orientation distribution. For each region we report average values for multi-compartment parameters (e.g. intra-neurite volume fraction and intrinsic diffusivity) and diffusion tensor metrics.
Multi-compartment metrics more specific to microstructure provide information complementary to diffusion tensor metrics in the cerebellum, thus giving new insights about microstructural correlations between regions.