4D flow MRI-derived 3D velocity and wall shear stress (WSS) maps in a large cohort of patients with aortopathy (n=515), stratified for valve morphology and stenosis severity, were compared with age-matched cohort-averaged maps of healthy controls (n=56) to yield maps of abnormally elevated hemodynamics. These maps were projected onto shared geometries and summed to map the incidence of abnormal velocity and WSS. Without stenosis, hemodynamics were significantly increased (Bonferroni corrected Mann-Whitney tests) in patients with bicuspid valves compared to patients with tricuspid valves. Incidence of elevated hemodynamics increased similarly for both cohorts (significant differences disappeared) with increasing stenosis severity.
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