Abstract #0790

Iron loss occurs in the deep gray matter of multiple sclerosis patients

Enedino Hernández-Torres^1,2, Vanessa Wiggermann^1,2,3, David K Li^2,4,5, Lindsay Machan⁴, A Dessa Sadovnick^5,6,7, Anthony Traboulsee^5,6, Simon Hametner⁸, and Alexander Rauscher^1,2

¹Department of Pediatrics, Division of Neurology, University of British Columbia, Vancouver, Canada, ²UBC MRI Research Centre, University of British Columbia, Vancouver, Canada, ³Department of Physics and Astronomy, University of British Columbia, Vancouver, Canada, ⁴Department of Radiology, University of British Columbia, Vancouver, Canada, ⁵Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada, ⁶Centre for Brain Health, University of British Columbia, Vancouver, Canada, ⁷Department of Medical Genetics, University of British Columbia, Vancouver, Canada, ⁸Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Vienna, Austria

In this work, a new approach for looking at the “iron deposition” in deep gray matter is presented. We investigated iron deposition in the deep gray matter indirectly by measuring R2^*. In addition, we assessed the normalized volume of the structures of the DGM. We found a stronger association between increases in R2^* and volume reductions of the same DGM structures in the MS group compared with the control group. Finally, we corrected the R2^* measurements by the volume of the structures (R2^*_m). The R2^*_m values were reduced in the MS group suggesting that iron accumulation is not a common feature of MS but on the contrary a redistribution/reduction of the iron takes place, which may be masked by structural atrophy.

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