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Abstract #0795

Spatial and Temporal Relationship between Microstructural and Morphological Abnormalities of Alzheimer’s disease: Evidence in Cortical and Deep Gray Matter

Nan-Jie Gong1,2, Chun-Chung Chan3, Lam-Ming Leung3, Chun-Sing Wong4, Russell Dibb5, and Chunlei Liu5,6

1University of California Berkeley, Berkeley, CA, United States, 2Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, NC, United States, 3United Christian Hospital, Hong Kong, 4The University of Hong Kong, Hong Kong, 5Duke University School of Medicine, 6Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, CA, United States

Non-Gaussian diffusion metrics such as MK from DKI can complement conventional MD and FA for detecting microstructural changes, especially in deep gray matter. This can potentially improve the efficacy of diffusion metrics for serving as diagnostic imaging biomarkers. We also provided evidence supporting the proposed notion that microstructural changes in cortical and deep gray matter predate macrostructural changes such as volume and cortical thickness.

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