Abstract #0825

Comparison of BOLD-contrast imaging and DW imaging for early prediction of renal damage after microemboli-induced acute kidney injury in animal model

Chengyan Wang¹, Hanjing Kong¹, Fei Gao², Wenjian Huang¹, Lian Ding¹, Rui Wang³, Li Jiang⁴, Yan Jia⁵, Hui Xu⁵, He Wang⁶, Xiaodong Zhang³, Li Yang⁵, Jue Zhang^1,2, Xiaoying Wang^1,3, and Jing Fang^1,2

¹Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, People's Republic of China, ²College of Engineering, Peking University, Beijing, People's Republic of China, ³Department of Radiology, Peking University First Hospital, Beijing, People's Republic of China, ⁴Philips Healthcare, Suzhou, People's Republic of China, ⁵Renal Division, Peking University First Hospital, Beijing, People's Republic of China, ⁶Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, People's Republic of China

Atheroembolic renal disease (AERD) is an important yet under-diagnosed kidney diseases associated with atherosclerosis. This study investigates the utility of BOLD and DWI in the assessment of microemboli-induced AKI, and compares the performances of both techniques for early prediction of renal damage. AKI was induced by injection of microspheres into the right kidney. The results indicate that both techniques can serve as reliable indicators to focal severe regional ischemia before renal damage occurs, while BOLD imaging seems to be more sensitive in early detection of moderate ischemia.

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