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Abstract #0838

Disentangling in two dimensions in the living human brain: Feasbilty of relaxometry-diffusometry using ultra-strong gradients

Chantal MW Tax1, Umesh S Rudrapatna1, Thomas Witzel2, and Derek K Jones1

1CUBRIC, Cardiff University, Cardiff, United Kingdom, 2MGH/HST Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, United States

Combining multiple, complementary contrasts into one analysis will yield deeper understanding of white matter physiology than using diffusion MRI (dMRI) alone. Varying TE in a PGSE sequence would allow for the exploration of D-T2 spectra in tissue. However, typical hardware and time constraints render the acquisition of such diffusion/relaxation spectra in the living human impractical. In this work, we explore how 300 mT/m gradients of a Connectom scanner could help in further investigating 1) the reported TE dependency of DTI parameters and 2) D-T2 spectra in the living human brain.

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