R2* mapping has been previously used to measure trabecular bone density by quantifying the magnetic field inhomogeneity effects induced by the susceptibility difference between trabecular bone and marrow. Quantitative susceptibility mapping (QSM) has been emerging in other body parts for measuring the field-independent magnetic susceptibility. Trabecular bone is in many locations embedded in yellow fatty marrow. Therefore, trabecular bone QSM requires to account for the presence of fat. The purpose of the present work is to develop a methodology for simultaneous R2* mapping and QSM of trabecularized yellow bone marrow and apply the technique in the calcaneus of healthy volunteers.