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Abstract #0881

Cervical spinal cord and brain MRS alterations in normal appearing white matter of multiple sclerosis (MS) patients at 3T

Patrik Oliver Wyss1,2,3,4, Anke Henning1,2,5, Andreas Hock1,6, Andreas Lutterotti7, Roland Martin7, and Spyros Kollias4

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 3Swiss Paraplegic Centre, Nottwil, Switzerland, 4Institute of Neuroradiology, University Hospital Zurich, Zurich, Switzerland, 5Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany, 6Department of Psychiatry, Psychotherapy and Psychosomatics Hospital of Psychiatry, University of Zurich, Zurich, Switzerland, 7Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital and University Zurich, Zurich, Switzerland

This investigation explores alterations of both cervical spinal cord and brain metabolite levels in normal appearing tissue in patients suffering from multiple sclerosis (MS). In the brain, a 2 dimensional J-resolved spectroscopy sequence and 2D prior-knowledge fitting is used and the metabolite cycling technique is applied to the cervical spinal cord at 3T. Relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) patients are included and alterations between brain and spinal cord metabolites are addressed.

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Abstract