Glycine, an inhibitory-neurotransmitter and a co-agonist of N-Methyl-D-aspartate, has been implicated in rapid cancer cell-proliferation and is elevated in high-grade gliomas than low-grade. Gly concentrations range from 0.5-1.0 M in normal brain and exhibits regional-variation. Given such a low in-vivo concentration of Gly, potential overlap from mI and regional-variation, here we have developed a novel Gly-optimized single-voxel-localized triple-refocusing scheme for precise co-detection of Gly and mI in Gray-matter (GM)-rich Medial-Occipital (MO) and White-matter (WM) rich Left-Parietal (LP) healthy-brain region, and further extended to measure glycine level in glioma patients.
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