Abstract #0894

Micro- and macro-structural development of the cortex in preterm infants

Dafnis Batalle¹, Hui Zhang², Jonathan O'Muircheartaigh^1,3, Antonios Makropoulos⁴, Emer Hughes¹, Madeleine Barnett¹, Paul Aljabar¹, Daniel C Alexander², Joseph V Hajnal¹, A David Edwards¹, and Serena J Counsell¹

¹Centre for the Developing Brain, Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, ²Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ³Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, ⁴Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, United Kingdom

We assessed micro and macrostructural cortical development in preterm infants using cortical curvature and thickness measures and neurite orientation and density imaging (NODDI). We studied two independent datasets of 64 and 42 neonates, and characterised the association between cortical features (median FA, MD, NDI, ODI, mean curvature and cortical thickness) and post-menstrual age (PMA) at MRI and gestational age at birth (degree of prematurity). We found a distinct pattern of development between the term (>37 weeks PMA) and preterm period (<37 weeks PMA), and different growth patterns between somatosensory and fronto-temporal areas.

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