Predicting cerebral palsy (CP) in infants with periventricular leukomalacia (PVL) is important for early treatment and rehabilitation. This study aimed to determine the crucial WM lesions in spastic CP (SCP) of non-cystic PVL infants using diffusion tensor imaging (DTI). Our results suggest that there was deceased FA in the corticospinal tract (CST) of bilateral SCP infants, but not in PVL infants without CP. Meanwhile, the posterior thalamic radiation, and the splenium of corpus callosum were damaged both in SCP and No-CP PVL infants. Therefore, Lower FA in the CST maybe a prerequisite and biomarker for identifying and predicting the outcome of SCP in infants with non-cystic PVL.