Abstract #0900

Quantitative susceptibility mapping in the neonatal brain with congenital heart disease

Zungho Zun^1,2,3, Kushal Kapse¹, Gilbert Vezina^1,3, Mary T Donofrio^2,3,4, and Catherine Limperopoulos^1,2,3

¹Division of Diagnostic Imaging and Radiology, Children’s National Medical Center, Washington, DC, United States, ²Division of Fetal and Transitional Medicine, Children’s National Medical Center, Washington, DC, United States, ³Departments of Radiology and Pediatrics, George Washington University, Washington, DC, United States, ⁴Division of Cardiology, Children’s National Medical Center, Washington, DC, United States

Brain injury is a frequent complication in newborns with complex congenital heart disease (CHD) secondary to hemodynamic instability and increased risk for hypoxic-ischemic injury. In this study quantitative susceptibility mapping (QSM) was performed in newborns with complex CHD prior to open heart surgery and was compared to healthy control newborns. Mean susceptibility was significantly higher in the cortical gray matter of neonates with CHD versus controls suggesting reduced oxygenation in the cerebral vasculature in CHD preoperatively. QSM images also depicted less contrast in the CHD, which may be associated with delayed brain development. This is the first report to demonstrate the feasibility of neonatal QSM and susceptibility differences between CHD and controls.

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