Conventional clinical liver MRI consists of several exams, including pre-contrast in-phase, opposed-phase, and fat-saturated scans as well as multiple scans with contrast-enhancement. For each of these acquisitions, accurate breath-holding is required to ensure diagnostic image quality.
Here, we demonstrate how this entire protocol can be replaced by using a single comprehensive exam, where only one dataset has to be acquired during free-breathing. All relevant images can be retrospectively generated with model-based fat/water separation, which incorporates compressed sensing and parallel imaging. This approach has the potential to improve clinical workflow and eliminate the risk for failed exams caused by imperfect breath-holding.