Degenerative cervical myelopathy (DCM) involves extrinsic spinal cord (SC) compression causing tissue injury and neurological dysfunction. Asymptomatic SC compression is much more common (8-26%), but it is unknown if tissue injury occurs in this group. Our multi-parametric MRI protocol previously identified 10 measures of tissue injury in DCM. Using these techniques, we demonstrate that asymptomatic SC compression subjects show a similar pattern of tissue injury, with 8/10 measures (p=0.05) showing the same direction of changes and MTRRostral (p=0.002), MTRMCL (p=0.03), and T2*w WM/GMRostral (p=0.04) showing significant univariate differences. A logistic regression model retaining 3 MRI measures shows 86% discrimination between compressed and uncompressed subjects.