Advanced imaging is a critical component in the development of patient-specific and novel treatment strategies, and the non-invasive evaluation of early response in sarcomas. Our central hypothesis is that changes in sarcoma stiffness quantified with MRE and perfusion with DCE-MRI throughout therapy can predict response. Soft tissue sarcomas are a rare malignancy arising in a wide range of anatomic locations. Anatomy-specific imaging protocols were developed to evaluate soft tissue sarcomas in 9 patients. In 3 patients, we investigated the feasibility to assess response to radiation therapy and observed a decrease in parameters related to tumor stiffness and perfusion metrics.