This study explores and demonstrates the opportunities opened by ultrahigh fields for in vivo CEST-weighted imaging. CEST-weighted fast spin-echo imaging was performed on two neurological models: hypoxic ischemic and glioblastoma. A remarkably strong CEST contrast (≈15%) was observed for the tumors at 3.32 ppm originating mainly from an APT increase and a strong decrease in NOE and MT. Ischemic lesions were still more robustly detected with standard T2-weighted images than with CEST. Potential explanations and dependence with high magnetic field are discussed.