Early Cancer Detection Using Paramagnetic Liposome by a Novel Contrast Mechanism with Active-feedback Magnetic Resonance Imaging

The detection of early tumors requires creating the contrast between healthy and tumor tissues that share a common morphology, making it difficult to distinguish them by relaxation-based MRI technique. Here we have exploited the small magnetic differences between the healthy and tumor tissues to develop a detection technique of early tumors using theranostic nanoparticle paramagnetic (Gd) liposome along with continuous wave (CW) irradiation in the presence of the feedback magnetic field from an active-feedback electronic device for in vivo subcutaneous glioblastoma multiforme mouse models and obtained significantly superior contrast compared to the conventional MRI technique, in agreement with spin-dynamics simulations.