Abstract #1033

Molecular imaging of inflammation and extracellular matrix remodeling in a murine model of myocardial infarction

Isabel Teixeira Ramos^1,2, Markus Henningsson¹, Maryam Nezafat¹, Begoña Lavin¹, Silvia Lorrio¹, Alkystis Phinikaridou^1,2, Ulrich Flögel³, Ajay Shah^2,4, and René Botnar^1,2

¹Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, ²Cardiovascular Division, The British Heart Foundation Centre of Excellence, King's College London, London, United Kingdom, ³Heinrich Heine University Düsseldorf, Düsseldorf, Germany, ⁴Cardiovascular Division, James Black Centre, King's College London, London, United Kingdom

A suitable degree and timely resolution of inflammation and extracellular matrix (ECM) deposition are requirements for optimal healing and remodeling after myocardial infarction (MI). In this study, we explored the merits of multinuclear ¹H/¹⁹F MRI for the simultaneous assessment and quantification of cardiac inflammation and elastin deposition in a murine model of MI. ¹⁹F containing particles, uptaken by macrophages, were used to investigate inflammatory cell recruitment into injured myocardium and an elastin-specific MR contrast agent was used to evaluate changes in elastin content in the ECM post-MI.

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