Directional and anisotropy measures from a diffusion model composed of VERDICT compartments were compared with directional and anisotropy measures from structure tensor analysis of registered histology images. A significant positive correlation was found between the direction of the Zeppelin component of the diffusion model (assumed to represent the extracellular space) and the predominant direction of the structure tensor from the stroma, where the primary feature is aligned collagen. The correlation of anisotropy measures was weak, which may be due to difficulties in detecting alignment in regions with densely-packed collagen, which have nearly uniform intensity on H&E staining.
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