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Abstract #1092

Isotropic Diffusion Weighted MRI (IDWI) – a novel, efficient clinical method for quantifying orientationally-averaged features of water diffusion in tissues

Alexandru Vlad Avram1, Joelle Sarlls2, Elizabeth Hutchinson3, and Peter Basser3

1NIBIB, National Institutes of Health, Bethesda, MD, United States, 2NINDS, National Institutes of Health, Bethesda, MD, United States, 3NICHD, National Institutes of Health, Bethesda, MD, United States

We propose a novel, efficient diffusion method, called isotropic diffusion weighted MRI (IDWI), for measuring orientationally-averaged properties of tissue water diffusion, free from modulations due to anisotropy. Using efficient diffusion gradient sampling schemes, IDWI rapidly and accurately quantifies the mean apparent diffusion coefficient (mADC) over a wide range of b-values, along with other important rotation-invariant intrinsic microstructural parameters, such as the mean t-kurtosis. The ability to efficiently and effectively remove modulations due to anisotropy in images with high-b values may improve existing diffusion MRI techniques and spur the development and clinical translation of new methods with improved biological specificity.

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