New clinical trials are using hyperpolarized 13C molecular imaging technology to evaluate tumor metabolic activity and response to targeted drug therapies. The goal of this work was to develop and apply an experimental setup for HP 13C MR investigations of cancer metastases to liver. In this study, patients with liver metastases were imaged and the results demonstrated sufficient SNR and data quality for the quantification of the localized conversion rate of [1-13C]pyruvate to [1-13C]lactate through lactate dehydrogenase (LDH), which is a pathway targeted by numerous emerging pharmaceutical agents and currently prescribed Everolimus.
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