Abstract #1118

Intravoxel incoherent motion diffusion-weighted MRI during chemoradiation therapy to monitor treatment response in human papillomavirus head and neck squamous cell carcinoma

Ramesh Paudyal¹, Jung Hun Oh¹, Nadeem Riaz², Praveen Venigalla², Jingao Li³, Vaios Hatzoglou⁴, Jonathan Leeman², David Aramburu Nunez¹, Yonggang Lu⁵, Joseph O. Deasy¹, Nancy Lee², and Amita Shukla-Dave^1,4

¹Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Radiation Oncology, Memorial Sloan Kettering Cancer Center, NY, United States, ³Radiation Oncology, Jiangxi Cancer Hospital, Chile, ⁴Radiology, Memorial Sloan Kettering Cancer Center, NY, United States, ⁵Radiation Oncology, Washington University in St. Louis, MO, United States

This study aims to monitor treatment response in human papillomavirus (HPV) head and neck squamous cell carcinoma using pre- and intra-treatment (TX) week 1, 2 and 3 imaging metrics derived from intravoxel incoherent motion (IVIM) DW-MRI. An unsupervised hierarchical clustering with a distance based on the Pearson correlation coefficient was performed using the relative percentage changes in D, f and D* to investigate similarities among features and samples. D showed a significant increase during treatment in complete response (CR) group. A heat map generated from the unsupervised hierarchical clustering identified subtypes in HPV positive [+] HNSCC patients.

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