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Abstract #1140

Magnetic Resonance Elastography of Emphysematous Rat Lung in vivo

Hongchen Wang1, Catherine Sebrié1, Georges Willoquet1, Jinlong Yue1, Felicia Julea1, Rose-Marie Dubuisson1, Sébastien Judé2, Anne Maurin2, and Xavier Maître1

1Imagerie par Résonance Magnétique Médicale et Multi-Modalités (UMR8081) IR4M, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France, 2Centre de Recherches Biologiques, CERB, Baugy, France

Emphysema is a chronic respiratory disease, which has become the fifth most common cause of death worldwide. Emphysema is characterized by alveolar wall destruction, leading to distal airspace enlargement and decreased elastic recoil. The altered structure and function of the lung is related to modified mechanical properties of pulmonary tissues, which are difficult to probe in vivo by standard techniques. Magnetic Resonance Elastography (MRE) allows to characterize the mechanical properties correlated with lung physiopathologies. Here, we implemented MRE lung imaging in vivo on emphysematous rat models.

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