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Abstract #1152

On- and off-target circuit effects of high frequency electrical deep brain stimulation at the subthalamic nucleus

SungHo Lee1, Daniel L. Albaugh1, You-Yin Chen2, and Yen-Yu Ian Shih1,3

1Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2National Chiao-Tung University, 3Neurology, UNC at Chapel Hill, Chapel Hill, NC, United States

This study introduces a novel hybrid methodology for DBS-fMRI research. Our findings demonstrate robust stimulus evoked fMRI and fcMRI responses during STN-DBS, which should shed light on how DBS exerts its therapeutic effects on whole-brain functional networks and delineate a road-map for future optimization of DBS therapy to enhance outcomes and reduce side-effects.

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