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Abstract #1159

GPR88 signatures on the reward resting state brain networks after alcohol exposure in mice

Tanzil Mahmud Arefin1,2,3, Sami Ben Hamida3,4, Thomas Bienert1, Thiago Marques De Melo1,5, Hsu-Lei Lee1, J├╝rgen Hennig1, Dominik von Elverfeldt1, Brigitte Kieffer3,4, and Laura-Adela Harsan1,6,7

1Advanced Molecular Imaging Center, Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, 2Faculty of Biology, University of Freiburg, Freiburg, Germany, 3Department of Translational Medicine and Neurogenetics, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, Strasbourg, France, 4Department of Psychiatry, Douglas Hospital Research Center, School of Medicine, McGill University, Montreal, QC, Canada, 5Spemann Graduate School of Biology and Medicine, University of Freiburg, Germany, 6Department of Biophysics and Nuclear Medicine, University Hospital Strasbourg, Strasbourg, France, 7Laboratory of Engineering, Informatics and Imaging, University of Strasbourg, Strasbourg, France

Identifying the genetic and molecular factors regulating the development and the dynamics of brain functional connectivity (FC) networks in health and disease is important to develop novel therapeutic strategies. Resting state functional magnetic resonance imaging (rsfMRI) can reveal the FC remodeling in psychiatric disorders and drug addiction. Emerging studies suggest that neuronal responses to alcohol involve several G protein-coupled receptors (GPCR)-mediated signaling pathways, inducing short-term to long-term changes in behavioral and neuronal plasticity. This study investigates the role of GPR88 in the acquisition and development of alcohol dependence and unravels the rsFC modifications underpinning this processes in the mouse brain.

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