Abstract #1165

Using simultaneous PET-MRI to investigate the mechanisms of neurodegeneration in frontotemporal dementia

Esther AH Warnert¹, Udunna C Anazodo², Kristy Coleman¹, Julia MacKinley¹, John Butler², Frank S Prato^2,3, Elizabeth C Finger¹, and Keith St. Lawrence^2,3

¹Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada, ²Lawson Health Research Institute, London, ON, Canada, ³Medical Biophysics, University of Western Ontario, London, ON, Canada

Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by progressive degeneration of brain function and structure. We present a proof-of-principle study in which simultaneous PET-MRI is used to inform on the pathophysiology of progressive neurodegeneration. By correlating glucose metabolism (PET) with functional connectivity (MRI), we found altered neuronal signaling in brain regions known to be critical in progression of FTD.

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