Simultaneous T1, T2 and Diffusion Quantification using Multiple Contrast Prepared Magnetic Resonance Fingerprinting
Yun Jiang1, Jesse Ian Hamilton1, Wei-Ching Lo1, Katherine L. Wright2, Dan Ma2, Andrew J. Coristine1,3, Nicole Seiberlich1, Vikas Gulani1,2, and Mark A. Griswold1,2
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Department of Radiology, University Hospitals of Cleveland, Cleveland, OH, United States, 3Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland
A novel MRF sequence is designed for generating high quality, distortion-free T1, T2 and apparent diffusion coefficient (ADC) maps simultaneously in less than 60 seconds per slice. The method inserts multiple magnetization preparation modules in a FISP-based MRF sequence. The use of magnetization preparation modules shortens the preparation time to achieve variable image contrast. Accurate T1, T2 and ADC quantification is demonstrated in a phantom and in vivo in human brains. This method enables the simultaneous collection of T1, T2 and diffusion maps for tissue characterization without the need to co-register separately acquired maps as in conventional MRI.
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