Thermal dose estimates and apparent diffusion coefficient (ADC) changes during MR-guided High Intensity Focused Ultrasound of painful bone metastases (n=11) were correlated with ablated tissue volumes assessed on Gd-T1W imaging acquired immediately, and at 30 days post-treatment. Thermal dose volume and mean maximum temperature were estimated from proton resonance frequency shift thermometry. Ablated tissue volume did not change significantly over 30 days. Mean maximum temperature and thermal dose volume were significant indicators of ablated volume, and mean maximum temperature was significantly higher in those with enduring ADC changes at Day 30. Further work will relate imaging changes to pain outcomes.