The increase in available dissolved-phase signal made possible by high-performing Xe-129 polarizers has led to renewed interest in dissolved-phase imaging of Xe-129 outside the lung. Here we examine the time course of the dissolved phase Xe-129 signal in the human kidney following gas inhalation, in order to optimize kidney image acquisition and explore the potential for studying kidney function using hyperpolarized Xe-129. In addition to spectral peaks commonly associated with Xe-129 dissolved in tissue/plasma, red blood cells, and fat, we have identified an additional peak at 201 ppm that lags the blood peaks by a few seconds.
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