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Abstract #1186

Quantitative ventilation-perfusion imaging using co-registered hyperpolarized gas and contrast enhanced 1H perfusion MRI

Paul John Clifford Hughes1, Bilal Tahir1,2, Felix C. Horn1, Alberto Biancardi1, Rob Ireland2, Helen Marshall1, and Jim Wild1,3

1POLARIS, Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 2Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom, 3Insigneo Institute for in silico Medicine, Sheffield, United Kingdom

Analysis of the matching of ventilation and perfusion using MRI is an important area of research in the pulmonary MRI community. This work presents a quantitative method of voxelwise analysis of ventilation from hyperpolarized gas MRI and perfusion from dynamic contrast enhanced 1H MRI. The method developed allows for direct comparison of ventilation and perfusion including global measurements of ventilated and perfused volume.

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