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Abstract #1192

Efficient IVIM of the Liver using Convex Optimized Diffusion Encoding Waveforms With Variable Flow Encoding Strengths

Kévin Moulin1, Eric Aliotta1,2, and Daniel B. Ennis1,2

1Department of Radiological Sciences, University of California, Los Angeles, CA, United States, 2Biomedical Physics IDP, University of California, Los Angeles, CA, United States

Accounting for the flow encoding strength α in addition to the b-value in the Intra-Voxel Incoherent Motion (IVIM) technique enables robust perfusion estimation. However, this approach still requires long scan times and α is dependent on both the diffusion encoding waveform and the b-value. In this study, waveforms were generated using the convex diffusion encoding (CODE) framework and led to a range of α for a given b-value. By sampling of flow- and diffusion-encoding space, capillary blood velocity (Vb), perfusion fraction (f) and true diffusion (D) was estimated with higher precision without any cost in time compared to conventional IVIM.

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