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Abstract #1207

Assessing the cellular distribution of iron in deep gray matter based on R2* and Quantitative Susceptibility Mapping (QSM) - Application to healthy controls and patients with Multiple Sclerosis (MS)

Yanis Taege1, Robert Zivadinov1,2, Jannis Hanspach1, Jesper Hagemeier1, Michael G Dwyer1, Balint P Sule1, Nicola Bertolino1, Dhaval Shah1, Dejan Jakimovski1, Niels P Bergsland1,3, Bianca Weinstock-Guttman4, and Ferdinand Schweser1,2

1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 2MRI Clinical and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 3MR Research Laboratory, IRCCS, Don Gnocchi Foundation ONLUS, Milan, Italy, 4BairdMS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States

This work introduces a clinically applicable technique to assess the cellular distribution of iron based on R2* and Quantitative Susceptibility Mapping (QSM). The method was applied to 68 MS patients and 29 controls, showing significant differences in the cellular iron distribution with age and disability.

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