Despite its strong relevance in metabolism, non-invasive measurement of adipocyte size remains an unmet need. High b-value DW-MRS has been previously applied to probe diffusion restriction effects of intramyocellular lipids or brown adipocytes using preclinical systems with strong gradient systems. The present work proposes a methodology to in vivo probe diffusion restriction effects in bone marrow adipocytes with high b-value long diffusion time DW MRS in a clinical system and examines the feasibility of bone marrow adipocyte size estimation in the tibia of healthy subjects.
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