Abstract #1241

Acquisition of sensorimotor fMRI under general anaesthesia in neurosurgical patients: evaluation of the effect of anaesthesia on the BOLD response.

Adam Kenji Yamamoto¹, Joerg Magerkurth², Laura Mancini³, Mark J White⁴, Anna Miserocchi⁵, Andrew McEvoy⁵, Ian Appleby⁶, Martin Smith⁷, John Thornton³, Nikolaus Weiskopf⁸, and Tarek A Yousry¹

¹Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, ²UCL Psychology and Language Sciences, Birkbeck-UCL Centre for Neuroimaging, London, United Kingdom, ³Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁴Medical Physics and Biomedical Engineering, University College London Hospital, London, United Kingdom, ⁵Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁶Department of Neuroanaesthesia, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁷Department of Neuroanaesthesia and Neurocritical Care, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁸Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

fMRI performed intra-operatively has the potential to significantly improve the outcomes from neurosurgery. The question remains however as to whether the BOLD signal can be detected in anaesthetised patients and what effect anaesthesia has on the response. In 5 patients with brain tumours anaesthetised for surgery we performed a passive sensorimotor fMRI paradigm. Anaesthesia resulted in a reduction in the BOLD response relative to the awake state, but also reduced the variance in the statistical model resulting in significant, accurate activation in all patients.

We conclude that the fMRI BOLD signal can be accurately detected in anaesthetised neurosurgical patients.

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