The reliability of fMRI for preoperative mapping of language areas depends on the paradigms used, as different tasks harness distinct capabilities to activate areas of speech processing. By comparing 3 language tasks [Silent Sentence Completion (SSC), Category Naming (CAT) and Word Generation (FAS)], we seek to determine the most robust and consistent task in localizing Wernicke’s area. Further the association between genomic markers and functional activation was determined. We included 15 healthy volunteers and 35 patients with gliomas. Results demonstrated that SSC is superior compared to other language paradigms and a correlation exists between tumor genomics and functional activation signals.